So I tried a mix of everything, clean game with only LSPDFR and nothing else, and it works fine. As soon as I Pile up other callouts/ plugins I start to have lags after 30min of game play and random drop frames in the city.
I understand that the more you add up, the harder it is for my computer. But some of you out there use a dozen plugins, and add interiors, and still make it playable.
No other mods, no scripts, I've tested it with 5REAL, as I have seen players using both succesfully, unfortunately for me having both kills my PC, and makes the game barely playable, so I don't know how they all do it (some have same PC specs as me).
And yes I checked, everything is up to date!