Try this, I just had the same problem:
Go into the Rage settings, and disable loading of plugins.
Save and Load game button.
Once in game, press F4, and type ReloadAllPluging (menu will auto populate, just select and hit tab).
Press F4 to exit.
Will take a few, but you will see your plugins load.
Boom. Should work.
If not, then at least you've narrowed down the issue to plugins, since the game loads into vanilla (assuming you can load game without loading plugins).
Good luck!
DrDetroit