I'm currently running NVR without any issues as of yet, though I haven't had a ton of time to play. If NVR causes any issues I'll edit this post with that.
So far I'm really enjoying 0.4. The first thing I noticed was that it seems like traffic stops have been refined quite a bit. In 0.3 the AI would just scoot over a couple feet and basically stop in the middle of the road. Every car I've stopped so far (albeit only a few) have pulled all the way over or even onto the sidewalk just a little, which I feel is way more realistic and safe for players- less likely to get hit by a car.
In terms of addons I've gotten ELS, EUP, NVR, SimpleFootControls, some custom vehicle models, and custom weapon models working without a hitch. I might also give some of Albo's mods a try just to see if any of them work, it seems like there's been mixed success with other people. Mostly I'd just like to have Computer+ and Smart Radio back, maybe Traffic Policer as well.
Been experiencing some performance loss even when just running LSPDFR on its own, so I don't think it's the mods doing it. My old system ran 0.3 fairly smoothly so I'm trying to figure out what's causing the FPS hit.
Aside from that, loving everything in 0.4!