Now there are all the tools that can make this possible! It would be entirely diffferent in terms of coding, since CP2077 relys on Lua, Redscript and other custom code. But there are so many possible ways. The easiest one might be Cyberscript Studio, which basically would allow creating something very complex already without even having to be a dev (for the most part). It features a powerful ingame editor for quests but also lets one create custom system. More advanced and even better would be CET and redscript, where both already offer quite a lot of ingame functions to be used by your own code, making it possible to use most of the native systems to add whatever you like - if you're capable. And the official modtools also allow to create your very own tools, now powered by some advanced creations like Red4Ext and other scripting extensions/hooks to get whatever you need. Same goes for modifying vanilla contents. This game would make a great NCPDFR mod for sure!
If there is someone or even a team willing to do this, now it's a good time. 😉