This is problem I have been having when I updated to a newer RAGEPlugin Hook and after I updated to Win 10. I can start the game normally through RPH the first time and LSPDFR will launch correctly. However, a few times after that, without fail, LSPDFR will crash while the game is starting with this error:

<spoiler>

[9/4/2015 6:45:12 PM.295] Plugin verification is disabled. Allowing plugin to run.
[9/4/2015 6:45:12 PM.296] Loading plugin from path: C:\Program Files (x86)\Steam\steamapps\common\Grand Theft Auto V\Plugins\LSPD First Response.dll
[9/4/2015 6:45:14 PM.743] <UNLOADED PLUGIN>: Initializing input system
[9/4/2015 6:45:14 PM.749] <UNLOADED PLUGIN>: Initializing game console
[9/4/2015 6:45:14 PM.753] <UNLOADED PLUGIN>: Initializing forms manager
[9/4/2015 6:45:14 PM.813] Plugin "LSPD First Response" was loaded from "LSPD First Response.dll".
[9/4/2015 6:45:14 PM.884] ---------------------------------------------------------------------
[9/4/2015 6:45:14 PM.884] LSPD FIRST RESPONSE
[9/4/2015 6:45:14 PM.884] Version 0.2b
[9/4/2015 6:45:14 PM.884] A G17 Media Modification
[9/4/2015 6:45:14 PM.884] - Developed by LMS & Sam
[9/4/2015 6:45:14 PM.884] - Special thanks to Cyan, Lt.Caine, Alexander Blade, The OpenIV Team, LukeD & MulleDK19
[9/4/2015 6:45:14 PM.884] © Copyright 2015, G17 Media, www.lspdfr.com
[9/4/2015 6:45:14 PM.884] ---------------------------------------------------------------------
[9/4/2015 6:45:14 PM.884] LSPD First Response: Running LSPD First Response 0.2b
[9/4/2015 6:45:14 PM.885] LSPD First Response: Copyright © 2015, G17 Media, www.lspdfr.com
[9/4/2015 6:45:15 PM.181] Cached police
[9/4/2015 6:45:15 PM.182] Cached police2
[9/4/2015 6:45:15 PM.182] Cached policet
[9/4/2015 6:45:15 PM.182] Cached sheriff2
[9/4/2015 6:45:15 PM.182] Cached sheriff
[9/4/2015 6:45:15 PM.182] Cached police4
[9/4/2015 6:45:15 PM.182] Cached policeb
[9/4/2015 6:45:15 PM.182] Cached policeb
[9/4/2015 6:45:15 PM.182] Cached policeb
[9/4/2015 6:45:15 PM.182] Cached fbi2
[9/4/2015 6:45:15 PM.182] Cached policeold1
[9/4/2015 6:45:15 PM.182] Cached policeold2
[9/4/2015 6:45:15 PM.182] Cached policeold2
[9/4/2015 6:45:15 PM.182] Cached buzzard
[9/4/2015 6:45:15 PM.182] Cached polmav
[9/4/2015 6:45:15 PM.182] Cached frogger2
[9/4/2015 6:45:15 PM.182] Cached ambulance
[9/4/2015 6:45:15 PM.182] Cached firetruk
[9/4/2015 6:45:15 PM.282] LSPD First Response: Folder is C:\Program Files (x86)\Steam\steamapps\common\Grand Theft Auto V\plugins\lspdfr
[9/4/2015 6:45:15 PM.303] LSPD First Response:
[9/4/2015 6:45:15 PM.304] LSPD First Response: ==============================
[9/4/2015 6:45:15 PM.305] LSPD First Response: UNHANDLED EXCEPTION DURING GAME THREAD TICK
[9/4/2015 6:45:15 PM.306] LSPD First Response: ------------------------------
[9/4/2015 6:45:15 PM.307] LSPD First Response: Origin: Game fiber "Plugin "LSPD First Response" main thread".
[9/4/2015 6:45:15 PM.308] LSPD First Response: ------------------------------
[9/4/2015 6:45:15 PM.309] LSPD First Response: Exception type: System.IO.IOException
[9/4/2015 6:45:15 PM.310] LSPD First Response: Exception message: The process cannot access the file 'C:\Program Files (x86)\Steam\steamapps\common\Grand Theft Auto V\plugins\lspdfr\HEROCOP.dll' because it is being used by another process.
[9/4/2015 6:45:15 PM.311] LSPD First Response: ------------------------------
[9/4/2015 6:45:15 PM.312] LSPD First Response: Inner exceptions:
[9/4/2015 6:45:15 PM.312] LSPD First Response: ------------------------------
[9/4/2015 6:45:15 PM.313] LSPD First Response: Stack trace:
[9/4/2015 6:45:15 PM.319] LSPD First Response: at System.IO.__Error.WinIOError(Int32 errorCode, String maybeFullPath)
[9/4/2015 6:45:15 PM.320] at System.IO.FileStream.Init(String path, FileMode mode, FileAccess access, Int32 rights, Boolean useRights, FileShare share, Int32 bufferSize, FileOptions options, SECURITY_ATTRIBUTES secAttrs, String msgPath, Boolean bFromProxy, Boolean useLongPath, Boolean checkHost)
[9/4/2015 6:45:15 PM.321] at System.IO.FileStream..ctor(String path, FileMode mode, FileAccess access, FileShare share)
[9/4/2015 6:45:15 PM.322] at System.IO.File.Open(String path, FileMode mode)
[9/4/2015 6:45:15 PM.323] at LMS.Common.AssemblyHelper.LoadFile(String path)
[9/4/2015 6:45:15 PM.324] at LMS.Common.AssemblyHelper.GetAllAssembliesInFolder(String folder)
[9/4/2015 6:45:15 PM.325] at ?.?()
[9/4/2015 6:45:15 PM.325] at ?..ctor()
[9/4/2015 6:45:15 PM.326] at LSPD_First_Response.Mod.Main.EntryPoint()
[9/4/2015 6:45:15 PM.327] at Rage.GameFiber.Main()
[9/4/2015 6:45:15 PM.327] LSPD First Response: ==============================
[9/4/2015 6:45:15 PM.328] LSPD First Response:

</spoiler>

I get this error every time afterwards. Even if I try to launch LSPDFR mid-game, it still gives the same error. I have removed all mods and it runs perfectly fine, and it doesn't matter what mod I remove, it still crashes LSPDFR often.

Reboot and run as administrator.