Also created account to post to this.
Play vanilla GTA. Windows 10 64 bit. After recent windows update issue began. Normally play with xbox one controller and mouse/keyboard. Switch between each depending on what is going on in game.
If the controller is plugged in none of the main keys on the keyboard work. F keys and home/end/pgup/pgdown work. escape and letters do not work. If the controller is unplugged the keyboard begins to work.
Related issue. If the game is launched with controller plugged in alt+tab out of the game causes GTA to crash.
Can not find any other postings of this issue anywhere else.
edit: Launching GTA with controller unplugged, then plugging in after game launch resolved issue.