Hey Guys,
Thanks for the replies, I actually sorted it out last night, I needed to install ScripthookV.dll and it fixed everything up. V.4 seems to be running smooth. I did not go back to Vanilla install as I have crappy internet and it would literally take me a day to re downloaded GTA, but I took my time and uninstalled/deleted all mods and plugins. Going to enjoy V4.0 for a bit until I start testing plugins that work with it.
Thanks again Tango and Will.