First of all you have to check that you have dsound.dll,scripthook.dll and else stuff for mods to work
Second- sometimes there are programs on your computer that conflicts with mods.Example:For me it was ESLWire program for CWs in Electronic Sports League,for another guy it was his keyboard with lots of things on it like monitor,some keys and when he shut it down everything worked.
Try to press lots of time, if they work after 7-10 hits then its conflict, if not then you dont have needed files for mod to work.
Best Wishes
LCPD Officer Garcia.
P.S. It might be SNT, so disable it by pressing Rctrl+R Alt+D or disable keys there in Options menu