Absolutely! This is a very real, dynamic environment to play (work) in... i decided to install GTA4 again fresh and just run vanilla cars (no ELS) and only a couple mods like Trainer etc... I dont get any crashes or lags etc... smooth as silk and stable as anything (apart from the noted bugs by the developers)..
To everyone who is getting crashes etc, why not simply reinstall and run in vanilla mode... then you will experience true gameplay without too many issues... so much fun its unreal!!!
Thanks to all the developers... they are some very talented people for sure!