rgminto

try these settings also what are the contents in your plugins folder ?
 
Main.PreloadAllModels = false
Networking.DisableServerCommunication = True
Networking.DisableDiscordRichPresence = True
Main.DisableAmbientScriptHooks = True
AmbientSpawn.MaxCopsInArea = 0
WorldEvents.IntervalMultiplier = 0
WorldEvents.MaxNumberOfEvents = 0
Callouts.Multiplier = 250
Chase.CopsCanCommandeerVehicles = false
Callouts.DisableBigRadar = true
Ambient.DisableAmbientGameCopSpawnBlock = true
Chase.DisableTrafficDensityAdjustments = true
Chase.ExhaustionInterval = 25000
Chase.ExhaustionDuration = 30000
AmbientSpawn.DisableRandomUnits = true
Chase.DisableAmbientAI = true
PoliceStation.DisableAmbientSpawn = true

you wont need to do for all models just the ones that exceed 25mb 

nope I experienced texture loss with 16gb of ram as imalcolm stated you must fix textures in the game using his method along with some other optimizations

what are your lspdfr settings ?
 
Here are mine and my settings along with a list of testing plugins that work with my computer between 50-60 fps with the new update hopefully this helps
 
Main.PreloadAllModels = false
Networking.DisableServerCommunication = True
Networking.DisableDiscordRichPresence = True
Main.DisableAmbientScriptHooks = True
AmbientSpawn.MaxCopsInArea = 0
WorldEvents.IntervalMultiplier = 0
WorldEvents.MaxNumberOfEvents = 0
Callouts.Multiplier = 250
Chase.CopsCanCommandeerVehicles = false
Callouts.DisableBigRadar = true
Ambient.DisableAmbientGameCopSpawnBlock = true
Chase.DisableTrafficDensityAdjustments = true
Chase.ExhaustionInterval = 25000
Chase.ExhaustionDuration = 30000
AmbientSpawn.DisableRandomUnits = true
Chase.DisableAmbientAI = true
PoliceStation.DisableAmbientSpawn = true
 

 

what are your lspdfr settings ?
 
Here are mine and my settings along with a list of testing plugins that work with my computer between 50-60 fps with the new update hopefully this helps
 
Main.PreloadAllModels = false
Networking.DisableServerCommunication = True
Networking.DisableDiscordRichPresence = True
Main.DisableAmbientScriptHooks = True
AmbientSpawn.MaxCopsInArea = 0
WorldEvents.IntervalMultiplier = 0
WorldEvents.MaxNumberOfEvents = 0
Callouts.Multiplier = 250
Chase.CopsCanCommandeerVehicles = false
Callouts.DisableBigRadar = true
Ambient.DisableAmbientGameCopSpawnBlock = true
Chase.DisableTrafficDensityAdjustments = true
Chase.ExhaustionInterval = 25000
Chase.ExhaustionDuration = 30000
AmbientSpawn.DisableRandomUnits = true
Chase.DisableAmbientAI = true
PoliceStation.DisableAmbientSpawn = true
 

 

Hey what are your graphic settings there are many things that can cause lag 
 
 
here is a link to a launcher that may help increase fps by 10 
https://www.gta5-mods.com/tools/gta-v-high-priority-launcher

you should try the following with some adjusted settings this might help 
https://www.gta5-mods.com/tools/gta-v-high-priority-launcher