This has happened to me after every major update that Rockstar releases and I am so sick of it.  Every time there is a major update get all of my mods updated and everything shl;uld be wokring fine, except now the game will not load.  I get into the loading screens and RPh has loaded everything, and the game just does not load.  I am stuck in the loading screens for ever.  I left in running for hours and still nothing.  The previous times I have had to reinstall my entire game and have not seen positive effects n my OC after having to do this so many times.  If anyone can help me that would be so much appreciated.  If you need additional info I can give it to you.  Thanks in advance.

You need to copy the Update2.rpf into your mods>update folder.  Replace it.  I need to remember that also.  I had to do that last time to solve the infinite loading screen.