2 GTAV Locations (Drives) on 1 PC

So, I running out of space on my Main Drive where GTAV/LSPDFR is.  Would be nice to keep it there since my Main (C) is a SSD with PCIe connection.  Really good speed wise but it is only 500GB and you know this game alone is a GB hog.  I bought a 2TB SSD SATA and I think I'll have to put the game on that.  I also have a 1TB HDD put I think SSD is the way to go with games.  I don't want to Move the game files.  I'm going to do a fresh install on everything and probably swap out plugins that aren't needed anymore.  I'm going to use LML to install the vehicles and stuff, before I was using Albo's DLC Modding Pack.  As I setup the game on the new ssd drive I would like to use the one on my main until the other is completely setup.  Problem I see is that you will have the game on 2 different drives on your computer.  I have retail version so can I do a fresh install on the new drive?  One problem is with OIV because it requires that it be linked to the game path.  How do I change paths back and forth between the 2 in OIV?  Any other problems that might come up doing that?  Any advice on how to do that would be great.