Make sure u have installed it good:
1) Install RAGE Plugin Hook - Open Alpha - 0.64.1234.15464 and LSPD First Response (Manaual install)
2) Drop every file from winrars to your game local file
3) Install OpenIV and open it
4) Locate your Gta 5 location (its in your disc > Rockstar Games > Grand Theft Auto V)
5) Go to Tools > ASI manager and install ASI Loader, OpenIV.Asi and opencamera.
6) Close OpenIV, and in your game local file right click on the ragepluginhook and enable "Open with administrator") And do it same with GtaV Launcher
7) Open Rage plugin hook and u will have settings, so only u will select it there, is "Load all plugins on start up"
8.) After settings, if ragepluginhook does not open, try to open Gta launcher, and after few seconds turn on the ragepluginhook
If u have installed it like that, turn off antivirus or try to reinstall gta 5 and install it again. If still does not works, tell me what is your game version.